Rehabilitation is the health strategy which, based on WHO’s integrative model of functioning, disability and health applies and integrates approaches with the goal to enable persons with health conditions experiencing or likely to experience disability to achieve and maintain optimal functioning. The function status associated with physical activity is a health indicator and is the domain of quality of life. Human functioning is a major target of the rehabilitation program.
Regenerative therapy could be done with introduction of stem cells, progenitor cells, or biologically active molecules and the implantation of bioengineered scaffolds or ex vivo grown tissues. Restoring or establishing normal function is the goal of regenerative medicine. Restoration of function from diseased or injured tissue is the ultimate goal of both regenerative medicine and medical rehabilitation interventions. Good performance in daily and sport activities could be done with intact anatomical, functional and biomechanical properties. Integration and healing of the surrogate cells, tissues, or organs after regenerative medicine intervention are often dependent on the fulfilling the therapeutic physical stimuli needs.
Strategies to maintain and/or improve proper cell function and survival within the environments they reside (origin and target tissue) and travel should be a primary focus for cell therapy. Individuals who receive regenerative therapies will require rehabilitation to make best use of their restored anatomy and newly regained abilities.
Regenerative rehabilitation represents a collaborative approach whereby rehabilitation specialists, basic scientists, physicians, and surgeons work closely to enhance tissue restoration by creating tailored rehabilitation treatments. This definition includes restoring function after tissue regeneration or repair, facilitating regeneration and repair at the tissue level during healing.
A part of regenerative rehabilitation which uses the biomechanical approach is mechanotherapy, which is defined as “any intervention that introduces mechanical forces with the goal of altering molecular pathways and inducing a cellular response that enhances tissue growth, modeling, remodeling, or repair.” The mechanotherapy will deliver mechanical signals (extrinsically eg with physical modality and intrinsically eg via therapeutic exercise prescription) to create a tissue force with the goal of evoking a cellular and molecular response. This process in turn activates specific biological responses in tissues to enhance the integration, healing, and restorative capacity of implanted cells, tissues, or synthetic scaffolds. Physical modality and exercise have the potential to influence any one, a combination, or all of these processes.
Penulis: DR. Dr. Damayanti Tinduh, SpKFR(K)