Universitas Airlangga Official Website

Regenerative Rehabilitation

IL by Resilia

Rehabilitation  is  the  health  strategy  which,  based  on  WHO’s  integrative  model  of  functioning, disability and health applies and integrates approaches with the goal to enable persons with health  conditions experiencing or likely to experience disability to achieve and maintain optimal functioning. The function status associated with physical activity is a health indicator and is the domain of quality  of life. Human functioning is a major target of the rehabilitation program.

Regenerative therapy could be done with introduction of stem cells, progenitor cells, or biologically active molecules and the implantation of bioengineered scaffolds or ex vivo grown tissues. Restoring or establishing normal function is the goal of regenerative medicine. Restoration  of  function  from  diseased  or  injured  tissue  is  the  ultimate  goal  of  both  regenerative medicine  and  medical  rehabilitation  interventions.  Good  performance  in  daily  and  sport  activities  could  be  done  with  intact  anatomical,  functional  and  biomechanical  properties.  Integration  and  healing of the surrogate cells, tissues, or organs after regenerative medicine intervention are often dependent on the fulfilling the therapeutic physical stimuli needs.

Strategies to maintain and/or improve proper cell function and survival within the environments they  reside (origin and target tissue) and travel should be a primary focus for cell therapy. Individuals who  receive regenerative therapies will require rehabilitation to make best use of their restored anatomy  and newly regained abilities.

Regenerative  rehabilitation  represents  a  collaborative  approach  whereby  rehabilitation  specialists,   basic  scientists,  physicians,  and  surgeons  work  closely  to  enhance  tissue  restoration  by  creating  tailored rehabilitation treatments. This definition includes restoring function after tissue regeneration or repair, facilitating regeneration and repair at the tissue level during healing.

A part of regenerative rehabilitation which uses the biomechanical approach is mechanotherapy, which is defined as “any intervention that introduces mechanical forces with the goal of altering molecular pathways  and  inducing  a  cellular  response  that  enhances  tissue  growth,  modeling,  remodeling,  or  repair.” The mechanotherapy will deliver mechanical signals (extrinsically eg with physical modality and intrinsically eg via therapeutic exercise prescription) to create a tissue force with the goal of evoking a cellular and molecular response. This process in turn activates specific biological responses in  tissues  to  enhance  the  integration,  healing,  and  restorative  capacity  of  implanted  cells,  tissues,  or  synthetic  scaffolds.  Physical  modality  and  exercise  have  the  potential  to  influence  any  one,  a  combination, or all of these processes.

Penulis: DR. Dr. Damayanti  Tinduh, SpKFR(K)

Link nya: https://www.indojournalpmr.org/IndoJPMR/article/view/137/104