Ketogenic diet is a popular diet in the community. The ketogenic diet is a diet strategy with a composition of high fat, low carbohydrates, and sufficient protein that is considered to be able to reduce weight gain quickly. Various research stated that the ketogenic diet effectively treats epileptic seizures, metabolic disorders, tumors, autosomal dominant polycystic kidney disease, and neurodegeneration. This diet has become popular because it is healthier than currently recommended.
The ketogenic diet has been reported to affect adiponectin. Adiponectin is a hormone produced by adipose tissue. Adiponectin is a biomarker of metabolic disease, a significant cardiovascular disease protective factor, and improves insulin sensitivity. The effect of the ketogenic diet on adiponectin is known to be contraindicative.
This study aimed to determine the effect of a ketogenic diet on the increase of adiponectin levels in mice (Mus musculus). This study used fourteen male mice that weighed 20-30 g, aged 2-3 months, and healthy. Mice were divided randomly into K1 (12% fat, 20% protein, dan 56% carbohydrate) dan K2 (60% fat, 30% protein, dan 10% fiber) given a diet for eight weeks. The result shows the difference of weight gain (∆) on K1 (12.00±6.26) g, K2 (1.29±7.41) g with p<0.005. The adiponectin serum K1 (0.082±0.014) μg/ml and K2 (0.096±0.008) μg/ml with p<0.035.
This study showed ketogenic diet-induced higher serum adiponectin compared to a standard diet. On the ketogenic diet, the body will experience a phase of ketosis due to decreased carbohydrate metabolism. This Ketosis results in ketone bodies, one of which is β-hydroxybutyrate (βHB), which plays a role in adiponectin level increase.
Author: Hamidah Kurniasari, S.Ked dan Dr Purwo Sri Rejeki, dr, MKes
Details of our study can be accessed on: https://www.e-journal.unair.ac.id/FMI/article/view/30223
Hamidah Kurniasari, Purwo Sri Rejeki, Hartono Kahar, Sri Sunarti, 2022. Effect Of Long-Term Ketogenic Diet In Mice Serum Adiponectin, Folia Medica Indonesiana Vol 8 (1), http://dx.doi.org/10.20473/fmi.v58i1.30223
